第十九期：母豬初乳中免疫球蛋白IgG與仔豬血漿中IgG含量的相關關系

zhutao19871018

2015. J. Anim.Sci. 93(9):4453-4462

母豬初乳中免疫球蛋白IgG與仔豬血漿中IgG含量的相關關系

初乳給新生仔豬提供能量和被動免疫，這對于仔豬的存活來說是非常關鍵的。仔豬血漿中IgG含量受多種因素影響，其中最重要的是母豬初乳中IgG含量。本試驗的主要研究不同母豬群和母豬個體之間初乳IgG含量的變異，以及影響仔豬血漿IgG含量的因素。本試驗包括4個母豬群（A-D），共62頭母豬和876頭仔豬。初乳取樣有三個時間點：在第一頭仔豬出生后和第一頭仔豬哺乳前（T1）、分娩中（第六頭仔豬出生后，T2）、最后一頭仔豬出生后（T3）。仔豬出生后第一天，收集仔豬血樣，并分析其中IgG的含量。母豬初乳中IgG平均含量為53.9g/L。A母豬群初乳IgG平均含量38.3g/L，B、C、D母豬群分別為47.4、60.4、67.8 g/L。T1、T2、T3時間點母豬的初乳含量分別為56.2、53.7、42.5 g/L。仔豬血漿IgG平均含量為21.7 g/L。以仔豬IgG含量為因變量進行多元線性回歸分析。在此模型中，母豬群的影響占總方差的9%，母豬層面的影響占總方差的34%。仔豬IgG含量與以下因素顯著相關：母豬群、出生順序（n）、體重指數（BMI＞17kg/m2）、T1初乳IgG含量（P＜0.01）。D母豬群仔豬IgG含量平均預測值最高。模型預測顯示，每晚出生一頭，仔豬血漿IgG含量降低0.4g/L（P＜0.01）。并且初乳IgG含量每提高1 g/L，仔豬血漿IgG含量可提高0.1 g/L（P=0.03）。體重指數大于17 kg/m2的仔豬與其他仔豬相比血漿IgG含量可提高4.5 g/L（P＜0.01）。初乳中IgG含量在不同豬群和個體之間變異非常大。仔豬血漿IgG含量的變異大部分還是由仔豬個體差異造成的，說明IgG自然生產和吸收的復雜性。但是，初乳和仔豬血漿中IgG含量的強相關關系表明提高初乳中IgG含量可以改善仔豬IgG水平，從而可能改善仔豬的存活率。

譯者注：體重指數是用體重公斤數除以身高米數平方得出的數字，是目前國際上常用的衡量人體胖瘦程度以及是否健康的一個標準。

The association between immunoglobulin G in sow colostrum and piglet plasma

C. Kielland, V. Rootwelt, O. Reksen and T. Framstad

Colostrum provides newborn piglets with energy and passive immunity and is essential for survival of the piglets. The plasma concentration of immunoglobulin G (IgG) in piglets is dependent on several factors, most importantly the concentration of IgG in sow colostrum (colostrum IgG). The main aims of this study were to nvestigate the variation in concentration of colostrum IgG between herds and the individual sows within herd and to investigate factors associated with plasma IgG concentrations in piglets (piglet IgG). From 4 herds (A to D), 876 piglets from 62 sows were included in the study. Colostrum was sampled from sows immediately after expulsion of the first piglet and before the first suckling (t1), midway through farrowing (just after the sixth piglet was born; t2), and after the last piglet was born (t3). At d 1, 0.5 mL blood from piglets was collected in tubes containing EDTA, and IgG concentrations were analyzed.Mean colostrum IgG concentration across all herds was 53.9 g/L. Herd A had mean colostrum IgG of 38.3 g/L, whereas the other 3 herds (B,C, and D) had mean colostrum IgG of 47.4, 60.4, and 67.8 g/L, respectively. Colostrum IgG at t1,t2, and t3 across all herds was 56.2, 53.7, and 42.5 g/L, respectively. Mean concentration of piglet IgG across all samplings was 21.7 g/L. Multilevellinear regression analysis was performed with piglet IgG (g/L) as outcome. In this model, the herd effect accounted for 9% of the total variance and 34% of the variance resided at sow level. Piglet IgG was associated with herd, birth order (n), body mass index (BMI) > 17 (kg/m2), and colostrum IgG at t1 (g/L)with an overall P-value < 0.01. Herd D had the highest predicted mean level of piglet IgG. The main model predicted that piglet IgG decreased linearly by 0.4 g/L with each piglet born (P < 0.01). The model also predicted an increase by 0.1 g/L for each gram per liter extra colostrum IgG in colostrum (P= 0.03). Piglets with a BMI above 17 kg/m2 had a greater piglet IgG (+4.5 g/L)than those with a BMI at 17 kg/m2 or below (P < 0.01). Concentrations of colostrum IgG varied largely between herds and between sows. The largest variation of piglet IgG was mainly on the piglet level, supporting the complex nature of IgG production and uptake. However, the strong association between colostrum IgG and piglet IgG shows that increased IgG level in colostrum will improve the levels of IgG in piglets and potentially increase survival of the piglets.

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